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Cumulative lead exposure and tooth loss in men: the normative aging study.

Identifieur interne : 000365 ( Main/Exploration ); précédent : 000364; suivant : 000366

Cumulative lead exposure and tooth loss in men: the normative aging study.

Auteurs : Manish Arora [États-Unis] ; Jennifer Weuve ; Marc G. Weisskopf ; David Sparrow ; Huiling Nie ; Raul I. Garcia ; Howard Hu

Source :

RBID : pubmed:20019902

Descripteurs français

English descriptors

Abstract

BACKGROUND

Individuals previously exposed to lead remain at risk because of endogenous release of lead stored in their skeletal compartments. However, it is not known if long-term cumulative lead exposure is a risk factor for tooth loss.

OBJECTIVES

We examined the association of bone lead concentrations with loss of natural teeth.

METHODS

We examined 333 men enrolled in the Veterans Affairs Normative Aging Study. We used a validated K-shell X-ray fluorescence (KXRF) method to measure lead concentrations in the tibial midshaft and patella. A dentist recorded the number of teeth remaining, and tooth loss was categorized as 0, 1-8 or > or = 9 missing teeth. We used proportional odds models to estimate the association of bone lead biomarkers with tooth loss, adjusting for age, smoking, diabetes, and other putative confounders.

RESULTS

Participants with > or = 9 missing teeth had significantly higher bone lead concentrations than those who had not experienced tooth loss. In multivariable-adjusted analyses, men in the highest tertile of tibia lead (> 23 microg/g) and patella lead (> 36 microg/g) had approximately three times the odds of having experienced an elevated degree of tooth loss (> or = 9 vs. 0-8 missing teeth or > or = 1 vs. 0 missing teeth) as those in the lowest tertile [prevalence odds ratio (OR) = 3.03; 95% confidence interval (CI), 1.60-5.76 and OR = 2.41; 95% CI, 1.30-4.49, respectively]. Associations between bone lead biomarkers and tooth loss were similar in magnitude to the increased odds observed in participants who were current smokers.

CONCLUSION

Long-term cumulative lead exposure is associated with increased odds of tooth loss.


DOI: 10.1289/ehp.0900739
PubMed: 20019902
PubMed Central: PMC2790506


Affiliations:


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Le document en format XML

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<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Aging (MeSH)</term>
<term>Environmental Exposure (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Lead (blood)</term>
<term>Lead (metabolism)</term>
<term>Lead (toxicity)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Risk Factors (MeSH)</term>
<term>Tooth Loss (blood)</term>
<term>Tooth Loss (etiology)</term>
<term>Tooth Loss (metabolism)</term>
<term>Young Adult (MeSH)</term>
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<term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Exposition environnementale (MeSH)</term>
<term>Facteurs de risque (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Jeune adulte (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Perte dentaire (métabolisme)</term>
<term>Perte dentaire (sang)</term>
<term>Perte dentaire (étiologie)</term>
<term>Plomb (métabolisme)</term>
<term>Plomb (sang)</term>
<term>Plomb (toxicité)</term>
<term>Sujet âgé (MeSH)</term>
<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
<term>Vieillissement (MeSH)</term>
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<term>Tooth Loss</term>
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<term>Tooth Loss</term>
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<term>Perte dentaire</term>
<term>Plomb</term>
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<term>Perte dentaire</term>
<term>Plomb</term>
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<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Aging</term>
<term>Environmental Exposure</term>
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<term>Adulte d'âge moyen</term>
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<term>Facteurs de risque</term>
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<div type="abstract" xml:lang="en">
<p>
<b>BACKGROUND</b>
</p>
<p>Individuals previously exposed to lead remain at risk because of endogenous release of lead stored in their skeletal compartments. However, it is not known if long-term cumulative lead exposure is a risk factor for tooth loss.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>OBJECTIVES</b>
</p>
<p>We examined the association of bone lead concentrations with loss of natural teeth.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>METHODS</b>
</p>
<p>We examined 333 men enrolled in the Veterans Affairs Normative Aging Study. We used a validated K-shell X-ray fluorescence (KXRF) method to measure lead concentrations in the tibial midshaft and patella. A dentist recorded the number of teeth remaining, and tooth loss was categorized as 0, 1-8 or > or = 9 missing teeth. We used proportional odds models to estimate the association of bone lead biomarkers with tooth loss, adjusting for age, smoking, diabetes, and other putative confounders.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>RESULTS</b>
</p>
<p>Participants with > or = 9 missing teeth had significantly higher bone lead concentrations than those who had not experienced tooth loss. In multivariable-adjusted analyses, men in the highest tertile of tibia lead (> 23 microg/g) and patella lead (> 36 microg/g) had approximately three times the odds of having experienced an elevated degree of tooth loss (> or = 9 vs. 0-8 missing teeth or > or = 1 vs. 0 missing teeth) as those in the lowest tertile [prevalence odds ratio (OR) = 3.03; 95% confidence interval (CI), 1.60-5.76 and OR = 2.41; 95% CI, 1.30-4.49, respectively]. Associations between bone lead biomarkers and tooth loss were similar in magnitude to the increased odds observed in participants who were current smokers.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>CONCLUSION</b>
</p>
<p>Long-term cumulative lead exposure is associated with increased odds of tooth loss.</p>
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